Sildenafil citrate, sold under the name Viagra is the first of a new group of medication which allows adequate sexual stimulation, relaxes the blood vessels of the penis and helps erection. Sildenafil tablet should be taken once a day. The time necessary for Sildenafil to exercise its action is about half an hour. The effect is maintained for about four hours.
The effect is only obtained with a satisfactory sexual stimulation.
Sildenafil relaxes muscles and increases blood flow to particular areas of the body.
Sildenafil under the name Viagra is used to treat erectile dysfunction (impotence) in men. Another brand of sildenafil is Revatio, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.
Sildenafil may also be used for purposes other than those listed here.
What should I discuss with my doctor before taking sildenafil?
Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid, and others), isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), and isosorbide mononitrate (Imdur, ISMO, Monoket). Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking sildenafil with a nitrate medicine can cause a serious decrease in blood pressure, leading to fainting, stroke, or heart attack.
A small number of patients have had a sudden loss of eyesight after taking sildenafil. This type of vision loss is caused by decreased blood flow to the optic nerve of the eye. It is not clear whether sildenafil is the actual cause of such vision loss. Sudden vision loss with sildenafil use has occurred most often in people with heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoke or are over 50 years old.
Before taking sildenafil, tell your doctor if you have:
heart disease or heart rhythm problems;
a recent history (in the past 6 months) of a heart attack, stroke, or heart rhythm disorder;
congestive heart failure;
high or low blood pressure;
coronary artery disease;
liver disease;
kidney disease;
a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia;
a bleeding disorder such as hemophilia;
a stomach ulcer;
retinitis pigmentosa (an inherited condition of the eye);
a physical deformity of the penis (such as Peyronie's disease); or
if you have been told you should not have sexual intercourse for health reasons.
If you have any of these conditions, you may not be able to use sildenafil or you may need a dosage adjustment or special tests during treatment.
FDA pregnancy category B: This medication is not expected to be harmful to an unborn baby. Do not use sildenafil without telling your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known if sildenafil passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take sildenafil?
Take each dose with a full glass of water.
Avoid taking High-fat food before taking Viagra as it may cause the medicine to take more time to start working.
Sildenafil is usually taken only when needed, 30 - 90 minutes before sexual activity. The medication can help achieve an erection when sexual stimulation occurs. An erection will not occur just by taking a pill.
Do not take sildenafil more than once a day. Allow 24 hours to pass between doses.
Store this medication at room temperature away from moisture and heat.
What happens if I miss a dose?
Viagra is used as needed, so you are not likely to miss a dose.
If you miss a dose of Revatio, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a sildenafil overdose may include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.
What should I avoid while taking sildenafil?
Avoid drinking alcohol, which can increase some of the side effects of sildenafil.
Avoid using other medicines to treat impotence, such as alprostadil (Caverject, Muse, Edex) or yohimbine (Yocon, Yodoxin, others), without first talking to your doctor.
What are the possible side effects of sildenafil?
If you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw during sexual activity, stop and call your doctor right away. You could be having a serious side effect of sildenafil.
Stop using sildenafil and get emergency medical help if you have sudden vision loss.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using sildenafil and call your doctor at once if you have any of these serious side effects:
chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
irregular heartbeat;
swelling in your hands, ankles, or feet;
shortness of breath;
vision changes;
feeling light-headed, fainting; or
penis erection that is painful or lasts 4 hours or longer.
Continue taking sildenafil and talk with your doctor if you have any of these less serious side effects:
warmth or redness in your face, neck, or chest;
stuffy nose;
headache;
upset stomach; or
back pain.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
What drug(s) may interact with ?
Do not take sildenafil if you are taking the following medications:
nitroglycerin-type drugs for the heart or chest pain such as amyl nitrite, isosorbide dinitrate, isosorbide mononitrate, nitroglycerin, even if these are only taken occasionally
Sildenafil may also interact with the following medications:
alpha blockers, used for high blood pressure or an enlarged prostate. NOTE: Do not take doses of sildenafil higher than 25 mg within 4 hours of taking alpha blockers, such as alfuzosin (UroXatral®), doxazosin (Cardura®), prazosin (Minipress®), or terazosin (Hytrin®).
bosentan
certain drugs used for seizures such as carbamazepine, phenytoin, and phenobarbital
certain drugs used for fungal or yeast infections, such as fluconazole, ketoconazole, and voriconazole
certain drugs for the treatment of HIV infection or AIDS
cimetidine
cisapride
clarithromycin
diltiazem
erythromycin
grapefruit juice
mibefradil
nitroprusside
rifabutin
rifampin
quinidine
some drugs for treating depression, anxiety or other mood problems (examples: fluoxetine, fluvoxamine, nefazodone)
verapamil
What is the shelf life of the pills?
The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.
Literatus: Happy accidents
IF YOU happen to believe that change or happenings take place only to those who are more religious than scientific, then you need to read more into the lives of scientists and inventors. read more
random ads inserted into web page?
my website: ups.uoftpharmacy.com has a bunch of random ads inserted into the source code after . The ad doesn't show up on the webpage, but it shows up when a snippet is taken of the page because it is right after and before the actual content. I checked my wordpress theme and it's clean. Other subdomains under the domain is clean as well. What can I do? Thanks! Excerpt from the HTML source code:
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Screening of Sildenafil, Vardenafil and Tadalafil in coffee by HPLC?
I have about 20 coffee samples purchased from local market with low prices. All samples were found to be negative for SD,TD,VD adulteration because result in different uv spectrum with library standard. Can someone suggest for me how do I make my discussion and conclusion?
What natural plant/herb is Viagra chemically extracted from?
How was the compound Sildenafil Citrate (Viagra) found and what was it extracted from?
Are Tadalafil Citrate (Cialis) and Vardenafil HCL (Levitra) extracted from the same plant source as Viagra is?
HELP!!! ANATOMY CASE STUDY!?
A 5’6”, 200lb., 50 year old male came in for a physical examination as part of investigations into possible causes of apparent infertility either in himself or his wife. They had been trying for a baby for over five years with no success. His blood pressure was >180/115 on three separate days. Further examination showed low plasma renin activity, elevated total peripheral resistance (TPR), cardiac output (CO) of 7.2L/min, x-ray evidence of the onset of left ventricular hypertrophy, mild retinal and epidermal petechiae, and mild polyuria. The patient also admitted experiencing some breathlessness with exercise and episodes of erectile dysfunction which he had attributed to the stress of the pregnancy efforts. The recommended therapy was weight reduction to his ideal level, a low-salt diet (<2gm/day sodium), prudent exercise, and a reduction in any alcohol consumption (<3oz whiskey/day). This change in lifestyle did little to change the condition. Medication was initiated in the form of an oral diuretic and progressed to a beta-blocker; eventually a vasodilator was included to reduce the blood pressure to <140/90. Once his blood pressure was stabilized, he was allowed to use 10mg tadalafil (Cialis) to treat the ED. ASPECTS TO RESEARCH: 1.The patient presents with an elevated BP. How is this related to the total peripheral resistance and the petechiae (include capillary dynamics)? 2.The plasma renin is low. What does this mean for the patient? Be prepared to explain your answer – what does renin do?, when & how is it released?, what does a low renin here mean?.
3.What would normally be happening to control the BP and what reason could there be for these mechanisms being ineffective?
4.Explain the CO value in this patient and the ventricular hypertrophy – think about the cardiovascular system, its regulation, and the patient’s physiognomy (ie. Size).
5.What is causing the polyuria?. 6.How are the urinary and lymphatic systems preventing peripheral edema?. 7.What effect does the patients weight have on his acid-base and fluid-electrolyte balances?
8.Why is the patient breathless after mild exercise? (think of factors that could be influencing the breathing itself, as well as any compensatory role the resp. system has physiologically).
9.Could any acid/base and fluid/electrolytes imbalances be related to the other symptoms?.
10.The initial treatment involved a low-salt diet. How will this help? (think in terms of the events in the digestive, urinary, and cardiovascular systems). 11.Relate his weight to the post-absorptive/absorptive states, his anabolic/catabolic states, and how altering his diet and lifestyle should be beneficial.
12.Account for the erectile dysfunction - how would altering his lifestyle, lowering BP, and using tadalafil help?
13.Along with the ED, what other factors could be leading to infertility and why?
14.Explain the rationale behind the pharmaceutical treatments used and the order in which they were given/attempted.
E.D.Problem?
I have erectile dysfunction problem.The medicine like sildenafil loses its effectiveness after some time.Even now caverject inj. are of little use.IS there any permanent cure for this problem let it be slow, or any specialist I couk\ld consult.
Health Highlights: Aug. 26, 2010
Title: Health Highlights: Aug. 26, 2010 Category: Health News Created: 8/26/2010 12:10:00 PM Last Editorial Review: 8/27/2010
Use & success of sildenafil citrate in PAH/PPH patients?
My wife suffering from PPH/PAH with RVH since 1980. She was on Nefidepine 20mg retard BD + Lasilactone 1 tab daily.
Last week her Cadiologist started sildenafil citrate 25mg BD & will increase to TDS dose of 25mg + Nifedipine20mg BD + Asprine 150mg 1 tab.
Voting Question: Tadalafil Megalis for an elderly diabetic?
My elderly dad of 70+ years was recently prescribed a medication that I found out is typically used to treat erectile dysfunction. This "doctor" supposedly told my diabetic dad that even though this medication (Tadalafil Megalis) is typically used to treat ED, my dad did not have to worry about increased blood flow to his penis as he is no longer sexually active - but that the medication should help in increasing blood circulation to his feet (his feet often swell up). Is this right?? I need a medical professional to comment on this so I can make sure that my dad is getting the appropriate treatment necessary. Thanks.
US FDA warns consumers not to take TimeOut capsules
The US Food and Drug Administration is warning consumers not to take TimeOut capsules because it contains an active drug ingredient that can dangerously lower blood pressure. The product is marketed as a dietary supplement for sexual enhancement.
FDA: TimeOut may pose risk
WASHINGTON, Aug. 27 (UPI) -- A dietary supplement marketed for sexual enhancement contains an active drug ingredient that may dangerously lower blood pressure, U.S. officials say. United States - Dietary supplement - Blood pressure - Food and Drug Administration - WASHINGTON